# Spectradyne (United States)
> “Spectradyne is the world leader in microfluidic nanoparticle analysis, producing instruments that measure the size, concentration, and fluorescent phenotype of individual nanoparticles using patented microfluidic resistive pulse sensing (MRPS) technology.”

- Canonical entity: https://directory.readyscan.ai/entities/spectradyne-united-states-q64142609
- Website listed in the source snapshot: https://nanoparticleanalyzer.com/
- Category: [Businesses](https://directory.readyscan.ai/directory/businesses)
- Machine record: https://directory.readyscan.ai/discovery/entities/spectradyne-united-states-q64142609.json
- Material fingerprint: fnv1a64:38699c0b946aa624
- Entity revision: fnv1a64:7ada71bd41c40efc
- Published: 2026-10-27
- Modified: 2026-10-27

## Questions & answers
### [What is MRPS?](https://directory.readyscan.ai/entities/spectradyne-united-states-q64142609#company-answer-content-native-digital-agencies-0315656ec124eae2-a-b68ce81913d97cabc87c)
“Microfluidic Resistive Pulse Sensing (MRPS) is Spectradyne's patented technology for measuring nanoparticles. As each particle passes through a precision-etched nanoconstriction in a microfluidic cartridge, it displaces electrolyte and generates a measurable resistance pulse. The amplitude of the pulse determines the particle diameter, providing real-time size and absolute concentration measurements for particles in the 50 nm to 10 micron range.”
Sources: https://nanoparticleanalyzer.com/faq/

### [What is the difference between the ARC and nCS2?](https://directory.readyscan.ai/entities/spectradyne-united-states-q64142609#company-answer-content-native-digital-agencies-0315656ec124eae2-a-25467032be7940d2c18c)
“Both instruments use MRPS to measure nanoparticle size and absolute concentration. The ARC additionally combines MRPS with single-particle fluorescence detection (F-MRPS), enabling simultaneous measurement of fluorescent subpopulations — such as payload-loaded LNPs or labeled EVs — in up to three optical channels. The nCS2 provides fast, accurate size and concentration measurements without fluorescence capability.”
Sources: https://nanoparticleanalyzer.com/faq/

### [How much sample is required?](https://directory.readyscan.ai/entities/spectradyne-united-states-q64142609#company-answer-content-native-digital-agencies-0315656ec124eae2-a-9cda49ad1c524a1979e5)
“Spectradyne instruments require only 2–3 microliters of sample per measurement, making them suitable for precious or scarce biological samples such as gene therapy vectors, extracellular vesicles, and clinical specimens.”
Sources: https://nanoparticleanalyzer.com/faq/

### [How does MRPS compare to DLS and NTA?](https://directory.readyscan.ai/entities/spectradyne-united-states-q64142609#company-answer-content-native-digital-agencies-0315656ec124eae2-a-5e1beadb6d0cd89fb957)
“Unlike DLS (dynamic light scattering) and NTA (nanoparticle tracking analysis), which measure bulk optical properties and cannot reliably resolve polydisperse mixtures, MRPS measures each particle individually using electrical sensing.”
Sources: https://nanoparticleanalyzer.com/faq/

## Company sources
- [Spectradyne (United States) website](https://nanoparticleanalyzer.com/) — nanoparticleanalyzer.com · [Related Ready Scan knowledge](https://readyscan.ai/sources/source-0315656ec124eae2)
- [nanoparticleanalyzer.com/faq/](https://nanoparticleanalyzer.com/faq/) — nanoparticleanalyzer.com · [Related Ready Scan knowledge](https://readyscan.ai/sources/source-0738861fd326e7e1)

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